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Objective To explore the long-term effects of sertraline on clinical symptoms,executive and occupational functions of patients with obsessive-compulsive disorder.Methods By randomly grouped,48 cases with obsessive-compulsive disorder were treated with sertraline as the study group and 44 cases treated with clomipramine as the control one.They were maintained with relative stable drug dosage after ill-condition improving,and all the subjects were also treated with psychological treatment and rehabilitation activities.The incidences of obsessive-compulsive symptoms before and after 2,4,6 and 8 weeks of treatment were investigated and compared.Yale-Brown obsessive-compulsive scale(Y-BOCS) were used to evaluate the efficacy according to the Y-BOCS reducing rate.The trail making test A and B (TMT-A and TMT-B),Stroop test and the Social Disability Screening Schedule (SDSS) were used at 8th weekend and 2 year's follow-up to evaluate and compare the two groups' executive and occupational functions.Results The incidences of 4 weeks' obsessive symptoms (62.5％)and 6 weeks' compulsive symptoms(18.8％) showed significantly lower in the study group than those in the control one (81.8％ and 38.6％,P＜0.05).But the obsessive-compulsive symptoms incidences at 8 weeks(8.3％-22.9％) and 2 years' treatment(6.3％-12.5％) in study group showed no statistical meaning differences from the control (20.5％-40.9％ and 15.9％-22.7％,P＞0.05).The clinical efficacy also showed no statistical difference between the two groups (P＞0.05).After two years' treatment,the times of TMT-B ((46.4±6.4) s) and Stroop-CW ((132.2± 14.9) s)of the study group showed significantly shorter than those of the control ((49.3±6.5) s,(138.8± 15.7)s,P＜0.05),and the total score and occupational function score of SDSS were significantly lower (P＜0.01) but the employment rates (72.9％)higher in the study group than those in the control (47.7％,P＜0.05).The total side-effect rate of the study group (12.5％) showed significantly lower than that of the control (43.2％,P＜0.05).Conclusion Sertraline is as effective as clomipramine for treatment clinical symptoms of obsessive-compulsive disorder.But it shows better long-term efficacy in improving executive and occupational social functions.
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Objective To explore the clinical effects of escitalopram combined with psychological interventions during peri-parturition period for patients with postpartum depression.Methods From July to December in 2012,totally 493 pregnant women were performed psychological interventions during peri-parturition period,and 34 cases of them who suffered from postpartum depression were treated with escitalopram l0mg daily combined with systemic psychotherapy as the study group.From January to June in 2012,totally 367 pregnant women were not performed psychological interventions during peri-parturition period,and 32 cases who suffered from postpartum depression were treated with escitalopram 10 mg daily and only with support psychotherapy as the control group.Both groups were observed for 8 weeks.The Hamilton rating scale (HAMD) and Clinical Global Impression-severity of illness (CGI-SI) were tested before treatment and after 1,2,4 and 8 weeks of treatment to evaluate the efficacy.The data were compared.Results The incidence of postpartum depression was 7.7％ in the study group which was significantly lower than that in the control (11.7％,x2 =3.96,P ＜ 0.05).At different time points after treatment(at the1st,2nd,4th and 8th week),the total scores of HAMD in the study group were 16.6 ± 3.8,12.4 ±3.2,8.8 ± 3.4,6.7 ± 2.3,respectively,which were lower than those in the control with statistically significant difference (19.4 ± 3.4,14.7 ± 3.0,11.2 ± 2.8,8.2 ± 2.7,respectively,x2 =2.43-3.15,P ＜ 0.05 or P ＜ 0.01).The CGI-SI scores of different time points after treatment in the study group showed significantly lower than those in the control group(P＜ 0.05 or P＜0.01).The side-effects showed no statistical difference between the two groups (P＞ 0.05).Conclusion Psychological interventions during peri-parturition period and escitalopram treatment combined with systemic psychotherapy in depression stage had better effects on preventing and curing postpartum depression.
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Objective To study the effect of family intervention on treatment compliance and social function for patients with schizophrenia.Methods 76 patients with schizophrenia were randomly divided into the intervention group and the control group with 38 cases in each group.The patients in both groups were treated with antipsychotics,the control group was only given general hygiene education,while the intervention group was given targeted systematic family intervention for 1 year.The Nurse-Brief Psychiatric Rating Scale (N-BPRS),Social Disability Screening scale (SDSS),Insight and Treatment Attitudes Questionnaire (ITAQ),medication adherence questionnaire were used before and after the intervention and then the recurrence rate within 1 year was calculated.Results At the end of 1 year the total scores of NBPRS,SDSS,medication adherence questionnaire significantly decreased in the intervention group and were signif-icantly lower than those of the control group at the same period,while the total score of ITAQ significantly increased in the intervention group and was significantly higher than those of the control group at the same period.The recurrence rate of the intervention group was significantly lower than the control group.Conclusions The family interventions contribute to promote insight recovery of the patients with schizophrenia ef-fectively and improve their treatment compliance,reduce recurrence and to promote the recovery of its so-cial function.
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Objective:To investigate the attentional bias for negative emotional facial expressions in major depressive disorder(MDD).Methods:Twenty MDD participants were selected from a larger pool of patients (n=35),diagnosed as depression with the Chinese Classification and Diagnostic Criteria of Mental Disorders Version 3 (CCMD-3),according to the Hamilton Depression Scale (HAMD) and Beck Depression Inventory (BDI).And 20 non-depression control participants(NC)matched with MDD group on age,gender and education level.All participants completed an exogenous cueing task which consisted of two kinds of cue types(valid and invalid trial)and two kinds of face types(neutral faces and negative faces).Results:Patients with MDD showed more larger cue validity effect for negative faces compared with neutral faces(21.73 ms vs.3.91 ms,P<0.01).They showed a stronger attentional engagement for negative faces in comparison with non-depressed participants(17.25 ms vs.1.64 ms,P<0.001).The NC group directed attention away from negative faces,more rapidly disengaging their attention compared with MDD,but the differences showed no significant(-1.50 ms vs.0.57 ms,P>0.05).Conclusion:These results support the assumption that MDD is associated with attentional bias for negative information,and deficits protective bias for it.
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Objective:To compare the efficacy of citalopram alone and citalopram combined with psychotherapy in patients with postpartum depression. Methods:Fifty-eight women who met CCMD-3 criteria for postpartum depression were randomly assigned to 2 groups. Group A was treated with citalopram 20mg daily alone, group B with citalopram 20mg daily combined with psychotherapy, both for six weeks. Hamilton rating scale (HAMD) was evaluated at baseline and after 1, 2, 4 and 6 weeks of treatment. Results:HAMD scores were decreased with statistical significance since week 1 in group A and since week 2 in group B. At different time points the HAMD scores in group A were lower than those in group B with statistically significant difference. Conclusion: Citalopram combined with psychotherapy was more effective than citalopram alone in the treatment of postpartum depression.